Is Wegovy Right for Women Over 40? What to Know Before You Start

Wegovy for women over 40: Learn how it works, who qualifies, and what to expect during perimenopause and beyond.

August 8, 2025

If you're a woman over 40 struggling with weight loss, you're not alone, and you're not imagining it. Hormonal changes, metabolic slowdown, and lifestyle shifts can all make it harder to lose weight, even with diet and exercise.

That’s why many women are now asking: Is Wegovy right for me?

Here’s what you need to know about Wegovy if you’re over 40, including how it works, who qualifies, and what to expect.

Why Weight Loss Gets Harder After 40

Starting in your 40s, estrogen levels begin to decline, especially during perimenopause and menopause. This hormonal shift can lead to:

Slower metabolism
Increased fat storage (especially around the midsection)
Reduced energy and sleep quality
Changes in hunger and satiety cues

These changes make weight loss harder, and keeping it off even harder. That’s where medications like Wegovy may help.

How Wegovy Works

Wegovy is a GLP-1 medication (semaglutide) that mimics a natural hormone in the body. It helps:

Reduce appetite
Regulate blood sugar
Improve feelings of fullness after meals

It’s taken once weekly as a small injection, and it works best when combined with sustainable changes to diet and lifestyle.

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Does Wegovy Work for Women Over 40?

Yes. Studies show that Wegovy is effective for adults of all ages, including women in their 40s, 50s, and beyond.

In clinical trials, Wegovy led to average weight loss of 15–18% of body weight, with some patients over 40 achieving even higher results when paired with consistent lifestyle changes.

However, everyone responds differently. Some women lose weight more slowly or experience more side effects, especially during dose escalation.

Eligibility for Wegovy

You may qualify for Wegovy if you:

Have a BMI of 30+, or
Have a BMI of 27+ with a weight-related condition like:
- High blood pressure
- PCOS
- High cholesterol
- Sleep apnoea
- Prediabetes or type 2 diabetes

If you’re not sure whether you qualify, an online consultation is a good place to start.

What to Expect in Your 40s and Beyond

Many women over 40 see meaningful results with Wegovy, but the journey can look a little different:

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Factor	What to Expect
Weight loss speed	May be slower than in younger users, especially if starting with a lower BMI
Side effects	Nausea and bloating are common at first — can be stronger during hormonal shifts
Progress plateau	Normal after a few months — adjusting dose or habits often helps
Muscle loss risk	Make sure to include strength training to maintain lean mass
Support matters	Ongoing doctor follow-up improves results and safety

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Get a Wegovy Prescription Today

Is It Safe for Perimenopause or Menopause?

Yes. Wegovy can be used safely during perimenopause and menopause, provided your prescribing doctor reviews any underlying conditions or hormone treatments you may be using.

There’s no known negative interaction between semaglutide and HRT (hormone replacement therapy), but it's important to disclose your full medical history during your consultation.

Final Thoughts

Wegovy can be a powerful option for women over 40 who want to take control of their weight. It's not a shortcut, but it is a clinically backed tool that may help you overcome the challenges of hormonal weight gain and metabolic slowdown.

If you’re ready to explore whether Wegovy is right for you, speak to a doctor or start a consultation online.