Managing Mounjaro Nausea and GI Side Effects

Nausea is one of the most common side effects of Mounjaro, affecting approximately 18% of patients. While usually temporary, it can be uncomfortable. Here are practical strategies to manage it effectively.

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Why Does Mounjaro Cause Nausea?

Mounjaro slows stomach emptying (gastroparesis), which is part of how it helps you feel full and eat less. However, this can also cause food to sit in your stomach longer, leading to nausea, especially when you eat too much or too quickly.

The good news: nausea is typically worst during dose escalation and usually improves within 4-8 weeks as your body adjusts.

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Dietary Strategies

Eat Smaller, More Frequent Meals

Instead of 2-3 large meals, try 4-5 smaller ones. This prevents overloading your stomach.

Avoid Trigger Foods

Common nausea triggers to avoid:

• Fatty, greasy, or fried foods
• Spicy foods
• Very sweet foods
• Rich, heavy meals

Choose Easy-to-Digest Foods

Focus on bland, simple foods during episodes of nausea:

• Crackers or plain toast
• Rice or plain pasta
• Bananas
• Clear broths
• Lean proteins

Eat Slowly and Mindfully

Take your time with meals. Put your fork down between bites. Stop eating as soon as you feel satisfied, not full.

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Timing Strategies

Consider Evening Injections

Many people find that injecting Mounjaro in the evening helps them sleep through the initial hours when nausea may be strongest.

Don't Eat Immediately After Injection

Give your body time to adjust after each dose. Avoid large meals for several hours post-injection.

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Other Helpful Tips

• Stay hydrated: Sip water throughout the day; dehydration can worsen nausea
• Get fresh air: Step outside or open a window when feeling nauseated
• Ginger: Ginger tea, ginger ale, or ginger supplements may help settle your stomach
• Avoid lying down after eating: Stay upright for at least 30 minutes after meals
• Peppermint: Peppermint tea or peppermint oil may provide relief

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When to Seek Medical Help

Contact your doctor if you experience:

• Severe or persistent vomiting
• Signs of dehydration (dark urine, dizziness, dry mouth)
• Inability to keep any food or fluids down
• Severe abdominal pain
• Nausea that doesn't improve after several weeks

Your prescriber may recommend slowing your dose titration or adjusting your treatment plan.

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Over-the-Counter Options

If dietary changes aren't enough, these may help (check with your pharmacist):

• Antacids for acid-related symptoms
• Simethicone for gas and bloating
• Antihistamine-based anti-nausea medications

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It Usually Gets Better

Remember, most people find that nausea significantly improves after the first few weeks at each dose level. Staying consistent with the strategies above will help you get through this adjustment period.

At Well Revolution, our care team can help you manage side effects and adjust your treatment plan as needed. We're available seven days a week to support you.