How much weight can you lose on Mounjaro? What trials suggest (and what’s realistic)

What clinical trials reported (big picture)

In large trials in adults with obesity (without diabetes), tirzepatide produced substantial average weight loss, generally increasing with higher maintenance doses and longer time on treatment.

• SURMOUNT‑1 reported average losses roughly in the mid‑teens to low‑20% range depending on dose.
• Many participants achieved clinically meaningful milestones (e.g., ≥10% and ≥15%).

Why real‑world results vary

• Dose you can tolerate and maintain
• Consistency with weekly dosing
• Nutrition quality and protein intake
• Strength training (muscle preservation improves body composition)
• Sleep, stress, and alcohol intake
• Medical factors (e.g., diabetes, PCOS, medications that influence weight)

A realistic timeline

Most people lose more in the first months and then slow down. Plateaus are common. A sustainable plan includes what you’ll do when progress slows.