What to Expect After Your First Wegovy Dose

Starting Wegovy is a big step, and it’s normal to wonder what comes next, especially after taking your very first dose. Whether you’re feeling great, unsure, or a bit nervous, here’s what you can expect in the hours and days following that first injection.

1. Most People Don’t Feel Much at First

If you’re starting at the recommended 0.25 mg dose, it’s completely normal not to notice any dramatic changes. This starting dose is designed to be gentle. Its main purpose is to help your body adjust to semaglutide and reduce the chance of side effects.

You may not feel any appetite suppression or weight loss right away, and that’s okay. The medication is still beginning to work in the background.

2. Mild Side Effects Are Possible

Some people experience mild side effects within the first few days, including:

• Nausea
• Bloating or gassiness
• Headache
• Fatigue
• Slight stomach discomfort

These effects are usually short-lived and improve on their own. Not everyone experiences side effects, and not having them doesn’t mean the medication isn’t working.

For a deeper dive, see Understanding Wegovy Side Effects: Causes and Effective Management

3. You Might Feel a Little Different — or Nothing at All

Some people report feeling a bit more full after meals, or a slight decrease in cravings. Others feel no change at all.

Either way, the first dose is all about getting started. Real appetite changes and weight loss tend to begin after the second or third dose, once your body has built up a bit more exposure to the medication.

4. It’s Important to Stay on Schedule

Wegovy is a once-weekly injection. Your second dose should be taken 7 days after the first, not sooner, even if you feel nothing. Injecting too early increases the risk of side effects without speeding up results.

If you’re unsure when your next dose is due, your care team can help.

5. Focus on Gentle Habits in Week One

While the medication is easing in, it helps to:

• Eat slowly and stop when you feel full
• Avoid overly rich or greasy foods
• Stay well hydrated
• Move your body, even just a walk

These small adjustments make it easier to handle upcoming dose increases.

6. When to Reach Out

Contact your doctor or care team if:

• You feel unwell or have questions
• You’re unsure about the timing of your next dose
• You want to check when to increase to the next dose

At Well Revolution, we check in regularly to guide you through each step and make sure everything’s on track.

The Bottom Line

After your first Wegovy dose, it’s normal to feel nothing, or just a little. The 0.25 mg dose is a gentle starting point, not a full treatment dose.

Give your body time to adjust. Stick to your schedule, build healthy habits, and reach out if you need support.

Start With Expert Support From Day One

At Well Revolution, we offer a free initial consultation to determine if Wegovy is safe and appropriate for you.

If prescribed, your $80 treatment plan includes:

• A prescription for 3 months of treatment
• A custom titration schedule (starting at 0.25 mg)
• Three months of expert medical care and follow-up
• Access to your dedicated doctor and care team any time

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